Colchicine is used to relieve acute gout and also for the prophylaxis of acute attacks, especially in the first months of treatment with allopurinol or Uricosurics. Colchicine induces a significant therapeutic response in acute gout by reducing inflammatory reactions to urate crystals. This action is due to several drug actions, including reduced leukocyte motility. Colchicine is not analgesic and has no effect on excretion or blood concentrations of uric acid.
It also has antimiotic (anti-parasympathetic) effects
Other uses for colchicine include:
Amyloidosis, Behcet’s syndrome, familial Mediterranean fever, idiopathic purpurathrombocytopenia, pericarditis and primary biliary cirrhosis.
If this medicine is prescribed for you to treat acute gout attacks, start taking the medicine immediately, the effects of using it will be created within 12 hours.
– Gout:Prevention of activation, degranulation and migration of neutrophils (by inhibiting the polymerization of beta-tubulin in microtubules)
Mediterranean fever: Impaired interleukin-1β activation (with impaired inflammatory complex in neutrophils and monocytes)